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The efficacy of dalbavancin for Staphylococcus aureus bloodstream infection caused by vancomycin-intermediate S. aureus (VISA) and daptomycin-intermediate S. aureus (dap-VISA) was compared with that of a 2-week duration of vancomycin plus gentamicin for inducible methicillin-resistant S. aureus (iMRSA) in hospitalized patients. Inpatients were eligible if they had community-acquired skin and soft tissue infection with a documented S. aureus and MIC of ≥1 µg/mL for daptomycin or ≥4 µg/mL for vancomycin by broth microdilution for screening. Enrollees were randomized 1:1 to receive either dalbavancin 7 mg/kg, administered intravenously over 2 days, or vancomycin 4 g plus gentamicin 40 mg/kg, administered intravenously over 2 days. The primary efficacy endpoint was failure of clearance within 48 hours, defined as the day of day 8 vancomycin minimum inhibitory concentration (MIC) measurement or day 13 if that was not performed. A total of 25 patients (17 men, 8 women; mean age, 57 years) were randomized to receive dalbavancin and 24 patients to receive vancomycin plus gentamicin. At the time of failure, 48% of patients in the dalbavancin arm had a vancomycin MIC of 4 µg/
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